3 mg to 5 mg administered as 0.5 mg/min or 0.2 mg/minute titration rate to slowly awaken the patient over 5 to 10 minutes.For repeat treatment, no more than 1 mg (at 0.2 mg/min doses) should be given at any one time and no more than 3 mg should be given in any one hour. Resedation may be treated by giving a repeat dose at no less than 20 minute intervals.Slow the rate of administration of flumazenil.Second dose: 0.2 mg IV may be given and repeated at 60-second intervals as needed (up to a maximum of 4 additional times) to a maximum total dose of 1 mg, if desired level of consciousness is not obtained after waiting 45 seconds.Common adverse reactions include diaphoresis, injection site pain, dizziness, headache, abnormal vision, blurred vision, agitation.Īdult Indications and Dosage FDA-Labeled Indications and Dosage (Adult) General Principles Overviewįlumazenil is a benzodiazepine receptor antagonist that is FDA approved for the treatment of reversal of conscious sedation induced with benzodiazepines. WikiDoc does not promote the administration of any medication or device that is not consistent with its labeling. The educational content on WikiDoc drug pages is based upon the FDA package insert, National Library of Medicine content and practice guidelines / consensus statements. WikiDoc is intended to be an educational tool, not a tool for any form of healthcare delivery. #Diazepam antidote flumazenil professionalWikiDoc is not a professional health care provider, nor is it a suitable replacement for a licensed healthcare provider. Associate Editor(s)-in-Chief: Gloria Picoy Disclaimer
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